Interleukin-1 in malnutrition.
نویسندگان
چکیده
The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 61 2 شماره
صفحات -
تاریخ انتشار 1986